MS Annika
MS Annika is a crosslink search engine based on MS Amanda , aimed at identifying crosslinks of cleavable and non-cleavable crosslinkers from MS2 and MS3 spectra.
MS Annika supports identification of protein-protein crosslinks from a variety of different cross-linking reagents, including cleavable and non-cleavable crosslinkers, and various acquisition workflows such as CID/HCD/stepped-HCD MS2 and MS2-MS3 acquisition.
MS Annika features an efficient algorithm for crosslink identification that allows for analysis of proteome-wide studies of both cleavable and non-cleavable crosslinkers on standard computer hardware.
MS Annika comes as user-friendly plugin for the proteomics platform Proteome Discover with a graphical user interface for easy setup and extensive documentation for customization.
Publications
You can read more about MS Annika here:
| Description | URL |
|---|---|
| MS Annika 3.0 Publication: | doi.org/10.1038/s42004-024-01386-x |
| MS Annika 2.0 Publication: | doi.org/10.1021/acs.jproteome.3c00325 |
| MS Annika 1.0 Publication: | doi.org/10.1021/acs.jproteome.0c01000 |
| IMP PD Nodes Website: | ms.imp.ac.at/?action=ms-annika |